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Ink stabilization during the course of tablet printing is not well understood. Of all the unit operations
used to produce finished tablets, tablet printing is the most susceptible to variations in room
conditions. Specifically, changes in room temperature, humidity or even the number of air changes
per hour can alter evaporation rates of the printing ink. This is especially true of alcohol based
inks. It is important to monitor both the incoming ink bottles and the ink in the ink well to assure
standardized ink printing conditions.
That’s right. In fact ink bottles can sometimes lose their vehicle, whether water or alcohol during
transit and storage. It is important to verify and, if necessary, re-dilute the concentrated ink back to
its original consistency before using it on line.
It is important to keep room conditions constant when printing tablets. Usually a room in the mid 60’
s to low mid 70’s is best with a constant humidity load is optimum for tablet printing. Don’t assume
that any room in the facility may be used for tablet printing; choose a room that you would expect to
compress or mill in, not an unused storage area or a part of a hallway blocked off for temporary
manufacturing use.
| Solid Dosage Training, Inc. FREE TECHNICAL HELP Printing |
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