| Solid Dosage Training, Inc. FREE TECHNICAL HELP Problem of the Month |
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| Problem of the Month February 2012 |
| Problem of the Month, February, 2012 Understanding the Role of The Impeller in High Shear Granulation The impeller is the center of any high shear granulator (HSG). It is important to study which type of impeller you have and also to understand any differences between any of the HSGs that you might have in you organization. Consider the two pictures of impellers that we see above. Both vessels are considered HSG but the impellers are of very different construction. If all other parameters are constant, there will still be a difference in the final wet mass due to this construction difference. And remember that in HSG based granulation there is always a bimodal distribution of gross and fine particles, of over and under granulated material. This can become an even bigger problem when the impellers are different. Especially important when you are scaling up or transfering a product from one facility to another. Next month we’ll talk about the chopper and what it does. Happy Valentine’s Day! |
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