| Tech Tip For Granulating: What Exactly is “Over granulating?” |
Over granulating results from using too much mechanical energy to mix the wet mass. It may also
occur from mixing too long, way past the end point. It may also occur from add too much binding
solution which results in almost a soup. As it the illustration below, granules are created through a
combination of mechanical energy and the quantity and addition rate of a binder. To some extent,
it is also a result of the concentration of the binder in the solution; although the literature generally
agrees that this is a lesser cause is regarded as a somewhat minor factor in most cases. Note
how granules form:
So at some point we have to determine when to “shut the process off”. From the eyeball’s point of
view, we are looking in most cases for a really damp powder mass without being liquid. And we
don’t want any rocks; that is granulation that has set up into large chunks and looks like a
wheelbarrow full of landscaping materials as seen in the photo below:
If we had stopped the process sometime before this mass of hard rocks was formed, we would
have had the best endpoint possible! But on the other hand at times a wet mass like that pictured
above may be successfully milled and compressed. Ibuprofen is just such a product, it sets up
easily and forms hard, construction like rocks and in most cases compresses just fine. But it is
usually best to stop the granulating process before we have the situation seen above.
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| Solid Dosage Training, Inc. FREE TECHNICAL HELP Granulating |
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