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There are of course many sizes and shapes of tablets to choose from when formulating.
There are relationships between the diameter of any tablet and its thickness. Some
formulators decide on what diameter tablet they want, then try and formulate around it.
And this is not necessarily bad. It’s just that the formulator, especially in nutritional
supplements, needs to understand that there is a limit what can be “fit” into any specific
diameter of a tablet. As you see in the table below, there are recommended targets and
limits associated with most any size and shape of tablet:
That’s a great start but it doesn’t tell the whole story. Remember it depends upon what you’
re putting in the tablet. A tablet with very little active ingredient will have a pretty big spread
around the target. A tablet with a calcium phosphate base will be denser and possibly allow
for a heavier tablet while a tab let with a high botanical content may have a lower bulk
density and allow less weight than the target.
This a convenient guideline so that tablets don’t end up with thicknesses the same as the
diameter. It’s important to consider the entire picture when you begin formulating.
| Solid Dosage Training, Inc. FREE TECHNICAL HELP Formulating |
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